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Under physiological conditions, cellular homeostasis is maintained through a delicate balance between pro-oxidative systems (comprising iron ions and reactive oxygen species) and antioxidant defenses mediated by the System Xc-/GSH/GPX4 axis

doi: 10.1038/oby.2007.53 139

Aging disturbs this delicate balance through mechanisms including impaired epithelial turnover, immune senescence, and shifts in microbial populations that favor pro-oxidant species